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M9480561.TXT
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1994-08-20
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33 lines
Document 0561
DOCN M9480561
TI Human T lymphotropic virus type I associated myelopathy and myasthenia
gravis: a possible association?
DT 9410
AU Fukui T; Sugita K; Ichikawa H; Negishi A; Kasai H; Tsukagoshi H;
Department of Neurology, Showa University School of Medicine,; Tokyo,
Japan.
SO Eur Neurol. 1994;34(3):158-61. Unique Identifier : AIDSLINE MED/94307313
AB We report the first known patient with human T lymphotropic virus type I
(HTLV-I) associated myelopathy (HAM) and myasthenia gravis (MG). A
50-year-old woman developed fluctuating muscle weakness with easy
fatigability, transient bilateral blepharoptosis and double vision.
Spastic paraparesis complicated these symptoms. Neurological assessments
and specific laboratory findings revealed that the patient had definite
HAM and MG. By inference from decreasing serum anti-HTLV-I antibody
titers after thymectomy, the presence of antigenicity for HTLV-I in the
thymic reticular cells, and a high incidence of various coexistent
autoimmune diseases in HAM or MG, we suggested the possibility that
these two diseases were associated with each other and with HTLV-I
infection.
DE Adult Aged Autoantibodies/ANALYSIS Carrier State Case Report Female
Human HTLV-I/*IMMUNOLOGY HTLV-I Antibodies/ANALYSIS Male Middle Age
Myasthenia Gravis/DIAGNOSIS/*IMMUNOLOGY/PATHOLOGY/THERAPY Paraparesis,
Tropical Spastic/DIAGNOSIS/*IMMUNOLOGY/PATHOLOGY/ THERAPY
Pyridostigmine Bromide/ADMINISTRATION & DOSAGE Receptors,
Cholinergic/IMMUNOLOGY Thymectomy Thymus Gland/PATHOLOGY JOURNAL
ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).